基于聚类分析的陆金根教授治疗炎症性肠病的用药规律(1)
摘要 目的：探讨和总结陆金根教授治疗炎症性肠病的学术思想和临床用药规律，探索名老中医经验整理的方法。方法：收集上海中医药大学附属龙华医院2011—2017门诊陆金根教授治疗炎症性肠病典型医案，对所选医案中符合纳入标准的药物运用Excel表进行收录，然后用SPSS 21.0 for windows统计软件进行聚类分析。结果：共有162份医案纳入研究，共计就诊622次，共得药物225味，出现的总频次为10411，常用中藥有白术、败酱草、白芍、大血藤、山药等27味。聚类分析发现清热解毒药、化湿药、理气药、补虚药、收涩药和活血化瘀药等为陆金根教授治疗炎症性肠病的常用配伍药类。红藤败酱散、白头翁汤、痛泻要方、参苓白术散、甘麦大枣汤等为陆老治疗炎症性肠病的基本方药。结论：陆老治疗炎症性肠病体现出“以清为主，清补结合”的学术思想。聚类分析结果客观反映了陆金根教授临床用药规律。
关键词 炎症性肠病;陆金根教授;聚类分析;用药规律;名医经验;中医药疗法;溃疡性结肠炎;克罗恩病
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Study on the Medication Rule of Professor Lu Jingen in Treating Inflammatory Bowel Disease Based on Cluster Analysis
Ding Chao，Liang Hongtao，Cao Yongqing，Wang Chen
(Department of Proctology，Longhua Hospital，Shanghai University of Chinese Medicine，Shanghai 200032，China)
Abstract Objective： To discuss and summarize clinical medication rule and academic idea of Professor Lu Jingen in treating inflammatory bowel disease，and to discuss the collection method of old famous Chinese medicine physicians′ experiences. Methods： The typical medical cases of inflammatory bowel diseases in the outpatient department from 2011 to 2017 in our hospital treated by Professor Lu Jingen were collected.Excel was used for the drugs that meet the inclusion criteria in the selected medical case，and then SPSS 21.0 for windows statistical software was used for Cluster analysis. Results： 162 medical cases were included with 622 visits.A total of 225 kinds of medicinal were obtained with total frequency of 10411.27 kinds of herbs were commonly used，including Rhizoma Atractylodis Macrocephalae，Herba Patriniae，Radix Paeoniae Alba，Caulis Sargentodoxae，Rhizoma Dioscoreae，etc.Cluster analysis showed that clearing heat and removing toxicity herbs，resolving dampness herbs，regulating vital energy herbs，tonifying deficiency herbs，astringent herbs and activating blood circulation to dissipate blood stasis herbs were often used in combination on treatment of IBD by Professor Lu Jingen.Hongteng Baijiang Decoction，Baitouweng Decoction，Tongxie Yaofang，Shenling Baizhu Powder，Ganmai Dazao Decoction were the basic prescriptions used by Professor Lu Jingen for the treatment of IBD. Conclusion： “Give priority to clearing，strike a proper balance between clearing and supplementing” is academic thinking of Professor Lu Jingen.The Cluster analysis results show objectively the rule of Professor Lu Jingen in using medicine for treating IBD.
Key Words Inflammatory bowel disease; Professor Lu Jingen; Cluster analysis; Medication rule; Experience of famous doctor; Traditional Chinese medicine therapy; Ulcerative colitis; Crohn′s disease, 百拇医药(丁超 梁宏涛 曹永清 王琛)
关键词 炎症性肠病;陆金根教授;聚类分析;用药规律;名医经验;中医药疗法;溃疡性结肠炎;克罗恩病
, http://www.100md.com
Study on the Medication Rule of Professor Lu Jingen in Treating Inflammatory Bowel Disease Based on Cluster Analysis
Ding Chao，Liang Hongtao，Cao Yongqing，Wang Chen
(Department of Proctology，Longhua Hospital，Shanghai University of Chinese Medicine，Shanghai 200032，China)
Abstract Objective： To discuss and summarize clinical medication rule and academic idea of Professor Lu Jingen in treating inflammatory bowel disease，and to discuss the collection method of old famous Chinese medicine physicians′ experiences. Methods： The typical medical cases of inflammatory bowel diseases in the outpatient department from 2011 to 2017 in our hospital treated by Professor Lu Jingen were collected.Excel was used for the drugs that meet the inclusion criteria in the selected medical case，and then SPSS 21.0 for windows statistical software was used for Cluster analysis. Results： 162 medical cases were included with 622 visits.A total of 225 kinds of medicinal were obtained with total frequency of 10411.27 kinds of herbs were commonly used，including Rhizoma Atractylodis Macrocephalae，Herba Patriniae，Radix Paeoniae Alba，Caulis Sargentodoxae，Rhizoma Dioscoreae，etc.Cluster analysis showed that clearing heat and removing toxicity herbs，resolving dampness herbs，regulating vital energy herbs，tonifying deficiency herbs，astringent herbs and activating blood circulation to dissipate blood stasis herbs were often used in combination on treatment of IBD by Professor Lu Jingen.Hongteng Baijiang Decoction，Baitouweng Decoction，Tongxie Yaofang，Shenling Baizhu Powder，Ganmai Dazao Decoction were the basic prescriptions used by Professor Lu Jingen for the treatment of IBD. Conclusion： “Give priority to clearing，strike a proper balance between clearing and supplementing” is academic thinking of Professor Lu Jingen.The Cluster analysis results show objectively the rule of Professor Lu Jingen in using medicine for treating IBD.
Key Words Inflammatory bowel disease; Professor Lu Jingen; Cluster analysis; Medication rule; Experience of famous doctor; Traditional Chinese medicine therapy; Ulcerative colitis; Crohn′s disease, 百拇医药(丁超 梁宏涛 曹永清 王琛)