阿托伐他汀对扩张型心肌病心力衰竭患者血清肝细胞生长因子水平的影响(1)
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【摘要】 目的 探讨阿托伐他汀对扩张型心肌病(DCM)合并心力衰竭患者血清肝细胞生长因子(HGF)水平的影响。方法 扩张型心肌病合并心力衰竭患者共60例 ，随机分为常规治疗与加用阿托伐他汀组各30例，治疗4周前后分别查血清HGF浓度和心脏左室收缩末期容积及左室射血分数，同时选择20例正常对照组。结果 血清HGF浓度在扩张型心肌病合并心力衰竭患者明显高于正常对照组差异有统计学意义(P<0.01)，治疗4周后，阿托伐他汀组左室收缩末期容积减少及左室射血分数提高更显著，但差异无统计学意义(P>0.05)。结论 扩张型心肌病合并心力衰竭患者血清HGF水平明显升高，短期阿托伐他汀可降低DCM患者的血清GHF浓度，该作用独立于其降血脂作用并与心功能的改善无关。
【关键词】 扩张型心肌病；肝细胞生长因子；阿托伐他汀
The effects of atorvastatin on HCF in patients with heart failure secondary to dilated cardiomycpathySUN Da-ying*,YU Feng-xiu.*The First Hospital affiliated to Haerbin Medical University,Daqing 163317,China
【Abstract】 Objective To study the effects of atorvastatin treatment on HGF and left ventricular function in patients with chronic heart failure secondery to dilated cardiomyopathy(DCM).Methods data from 60 patients were randomly divided into conventional therapy and plus atorvastain group,4 weeks after treatment.Results HGF levels in atorvastatin group significantly decreasedP<0.01 ......
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