玻璃酸钠联合曲安奈德关节腔内注射治疗膝骨性关节炎的疗效观察(1)
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[摘要] 目的：观察玻璃酸钠联合曲安奈德关节腔内注射治疗骨性膝关节炎的疗效。方法：将101例患者随机分为4组，联合治疗组选择30例骨性膝关节炎患者，关节腔内联合注射玻璃酸钠和曲安奈德，玻璃酸钠每周1次，共5次，曲安奈德第1周和第3周注射，共2次。曲安奈德组仅关节腔内注入曲安奈德。玻璃酸钠组仅关节腔内注射玻璃酸钠。对照组仅关节腔内注射0.9%氯化钠溶液。观察和比较治疗前、治疗后1个月和治疗后6个月膝关节功能评分结果。结果：治疗后1个月和治疗后6个月膝关节功能评分显著好转，并疗效优于单用玻璃酸钠或曲安奈德(P<0.05)。结论：玻璃酸钠联合曲安奈德关节腔内注射可以明显改善骨性膝关节炎的临床症状，远期效果较好，而且副作用少。
[关键词] 玻璃酸钠；曲安奈德；骨关节炎；膝关节；关节腔内注射
[中图分类号] R684.3 [文献标识码] B [文章编号] 1674-4721(2011)12(b)-058-02
Therapeutic effect of intra articular injection with sodium hyaluronate and triamcinolone acetonide for knee joint osteoarthritis
FENG Zhenwei, XIANG Xin, HUANG Diansheng, HE Kun, Shi Yanchun, HUANG Zhenhua
Nephropathy Rheumatism Department of Guangxi National Hospital, Nanning 530001, China
[Abstract] Objective: To observe the therapeutic effect of intra articular injection with sodium hyaluronate and triamcinolone acetonide for knee joint osteoarthritis. Methods: One hundred and one cases of osteoarthritis were randomly divided into three groups, combined treatment group were given inject combined with sodium hyaluronic (once a week for 5 consecutive weeks) and triamcinolone acetonide (once at the first and third week for 2 consecutive weeks). Sodium hyaluronate group were only given injection with sodium hyaluronate, triamcinolone acetonide group were only given injection with triamcinolone acetonide, control group were only given injection with 0.9% NaCl. The therapeutic effect was observed and compared before treatment, 1 month after treatment and 6 months after treatment. Results: The combined group had significantly difference compared to the other groups (P<0.05 ). Conclusion: Symptoms of knee joint osteoarthritis is improved by intra-articular injection with sodium hyaluronate and triamcinolone acetonide, with little side effect.
[Key words] Sodium hyaluronate; Triamcinolone acetonide; Osteoarthritis; Knee joint; Intra-articular injection
膝骨性关节炎(简称膝OA)是中老年人临床上常见的慢性进展性关节疾病，以关节软骨进行性变性、破坏，关节骨端反应性增生为其病理基础，目前尚无理想的治疗方法。笔者2007年6月~2009年10月年应用玻璃酸钠加曲安奈德注射液治疗30例膝关节骨性关节炎患者，对改善关节功能，减轻关节疼痛，缓解病程取得了较好的疗效。
1 资料与方法
1.1 一般资料
选取2007年6月～2009年10月在本科门诊和住院的101例确诊为膝骨性关节炎的患者为研究对象，均符合1995年美国风湿病学会的诊断标准[1]：①1个月来大多数时间有膝痛；②X线片示膝关节骨端边缘有骨赘形成；③膝关节活动时有摩擦声响；④膝关节周围有肿胀；⑤年龄40岁；⑥晨僵时间≤30 min；⑥具备①、②或①、③、⑤、⑥或①、④、⑤、⑥等表现即可确诊为OA ......
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